Homocysteine Neuro Challenge (Methylation)
Homocysteine Neurological Challenge (Methylation Challenge)
Methlyation disorders are associated with eleveated homocysteine and can be foun din conditions such as Parkinson’s disease, Alzheimer’s Disease, and other neurodegenerative disorders. Excess homocysteine converts to homocysteic acid with excitatory neurotransmitter effects similar to aspartate (ASP) and glutamate (GLU). Aspartate, glutamate, and homocysteic acid are excitatory to the N-methyl D-aspartate (NMDA) receptor.
What occurs with elevated homocysteine is that a vicious cycle is generated that ends not only in that cell’s death, but also in a spreading cell death of surrounding cells.
What does it test for?
Assesses the patient’s ability to metabolize homocysteine and their current ability to perform necessary methylation reactions.
How does Dr. Anderson perform the test?
Using the manual muscle test as an indicator, a strong muscle will weaken when the patient is exposed to homocysteine. In addition, if impaired methylation is suspected the patient may be challenged with Methionine or SAMe and observe if a weak muscle strengthens, suggesting a need for more.
What does it mean?
The inability to metabolize homocysteine and impaired methylation have significant clinical ramifications. It has been linked to heart disease, cancer, stroke, autism, and many other conditions. If the patient has difficulty with metabolizing homocysteine they more than likely have difficulty with methylation in general. Methylation is the ability for our body to add a –CH3 group to a chemical compound.
Methylation is an essential component of genetic expression, embryonic development, postnatal development, cancer prevention, immune function, liver detoxification and many other biochemical processes. It is an extremely extensive and broad topic of current research and it would be impossible to summarize all of the clinical ramifications in a paragraph. From a holistic and natural health care point of view, impaired methylation can be improved by proper supplementation and overall reduction of toxic load.
The manual muscle test can be a beneficial tool to utilize when a patient has impaired methylation. In addition, the nutrients required for optimal methylation are checked frequently throughout my treatment protocol during other biochemical assessments.
Mg, B-12, Folic Acid, B6, Betaine, Choline, Methyl Donors
Foods to Avoid
Our body’s methylation requirements will be increased if our toxic load is high. This appears to be one of the main reasons why more and more people have impaired methylation. As a society our environmental toxic load continues to increase with no signs of turning around. Therefore, in order to improve our methylation we need to avoid toxic foods, which are basically processed foods, additives and preservatives of any kind.